Probiotics for intimate and intestinal flora

A balanced microbiota is the foundation of optimal health and our intestinal and intimate flora are populated with good and "bad" bacteria.

Probiotics support the balance of our flora by populating it with beneficial microorganisms.

There are many factors that can damage or unbalance the microbiota (diet, stress, illnesses, taking certain treatments, etc.). Probiotics thus contribute to the balance of the intestinal flora.

On the intimate sphere:
The vaginal microbiota is mainly composed ofLactobacillus,lactic acid bacteria that maintain an acidic environment to prevent the proliferation of certain pathogenic bacteria. In the event of an imbalance in the vaginal flora (known as “dysbiosis”), the content ofLactobacillusis lower and the vaginal pH increases, creating a playground conducive to the growth of unwanted microorganisms, generally responsible for intimate discomforts (such as vaginosis, vaginal mycosis, vaginitis, etc.)

On the intestinal sphere:
The gut microbiota plays a key role in metabolic, immune and barrier functions. However, an imbalance can lead to certain digestive discomforts such as diarrhea, flatulence or constipation.

On the maternity journey:
Can probiotics play a role? Several studies show an interest at each stage of motherhood.

• In pre-conception:An “unbalanced” vaginal microbiota couldnegatively affect the chances of pregnancy. A scientific study has also shown that an intimate microbiota poor inLactobacilluscould significantly decrease implantation, pregnancy, and live birth rates, highlighting the importance of a healthy vaginal microbiota for conception. Additionally, one review observed that the vaginal microbiota of fertile women was dominated byLactobacillus spp. whereas non-fertile women had an unbalanced microbiota. Thus, probiotics could have a positive role in reproductive health. [8-11]

• In the PMA process:The use of probiotics is encouraged by many health professionals in the medium term. For women engaged in a medically assisted procreation process, a balanced microbiotacould play a role in nesting success, thus the implantation of the embryo in the uterus. Certain probiotics, by supporting hormonal balance and helping to modulate inflammation,could help create a more welcoming environment for the embryo. Thus, integrating probiotics before PMA would promote optimal conditions for implantation and increase the chances of success. [10]

• During pregnancy:A scientific review suggests that a microbiota poor inLactobacilluscould be associated with a higher risk of preterm birth, compared with a vaginal microbiota dominated byL. crispatus. [12] Another study showed that babies born vaginally had bacterial communities similar to their mother's vaginal microbiota. Thus, if the mother's vaginal microbiota is poor inLactobacillus, this could influence the composition of the newborn's microbiota. [13]

• Postpartum:Some probiotics such asL. rhamnosushave shown promising results on emotional well-being. [14,15]

Our Probiotics product brings together a set of lactic ferments necessary for intestinal flora and intimate flora.

Health claims:

Probiotics contribute to the balance of intestinal flora.
Vitamin B2 contributes to the maintenance of normal mucous membranes.

To take full advantage of the benefits of our Probiotics treatment, a few simple actions can make all the difference. Here are our recommendations to ensure optimal use:

How do I take my treatment?

Take 1 capsule per day with a large glass of water, preferably in the morning. This routine ensures a constant daily intake of beneficial bacteria.

It is recommended to take probiotics on an empty stomach, about 30 to 15 minutes before breakfast. If you prefer to take them at another time of the day, just make sure to consume them away from meals (minimum 2 hours) and away from hot drinks that could impact the effectiveness of the treatment.

Duration and regularity:

A minimum 3-month treatment is recommended. Consistency is key to fully feeling the benefits of our Probiotics treatment. Prolonged consumption is possible, this allows good bacteria to establish themselves and restore the microbial balance in a sustainable manner.

Storage conditions:

To preserve the quality of the strains, store the capsules in a cool, dry place. Our Probiotics are stored in a cool place upon manufacture, as well as in our logistics warehouse to preserve their effectiveness. At home, ideally place them in the refrigerator to ensure their freshness and long-term benefits. Although our probiotics are stable at room temperature, refrigerated storage prolongs their effectiveness.

Who can take Probiotics? 

Any woman concerned about her intestinal health and intimate well-being, during the maternity journey (preconception, pregnancy, postpartum), or at any time in life. Ideal in case of imbalance of the intimate and/or intestinal flora.

Probiotics is compatible in case of pregnancy and/or breastfeeding. However, do not hesitate to speak to your healthcare professional before any supplementation.

Our Probiotics food supplement is also suitable for men.

Cannot be substituted for a varied and balanced diet and a healthy lifestyle.

Do not exceed the recommended daily dose.

Keep away from heat, humidity and out of reach of young children.

For adults only.

Pregnant and breastfeeding women are advised to consult a healthcare professional before taking any supplements.

Bibliographic references:
[1]Grattepanche, Astrid Cécile Emma. “Gynecological probiotics in pharmacies”, nd

[2]Mändar, R., G. Sõerunurk, J. Štšepetova, I. Smidt, T. Rööp, S. Kõljalg, M. Saare, et al. “Impact of Lactobacillus Crispatus-Containing Oral and Vaginal Probiotics on Vaginal Health: A Randomized Double-Blind Placebo Controlled Clinical Trial,” April 14, 2023.https://doi.org/10.3920/BM2022.0091.

[3]Gudnadottir, Unnur, Justine W. Debelius, Juan Du, Luisa W. Hugerth, Hanna Danielsson, Ina Schuppe-Koistinen, Emma Fransson, and Nele Brusselaers. “The Vaginal Microbiome and the Risk of Preterm Birth: A Systematic Review and Network Meta-Analysis”.Scientific Reports12, no 1 (May 13, 2022): 7926.https://doi.org/10.1038/s41598-022-12007-9.

[4]Slykerman, RF, F. Hood, K. Wickens, J.M. Thompson, C. Barthow, R. Murphy, J. Kang, et al. “Effect of Lactobacillus Rhamnosus HN001 in Pregnancy on Postpartum Symptoms of Depression and Anxiety: A Randomized Double-Blind Placebo-Controlled Trial.”EBioMedicine24 (October 2017): 159‑65.https://doi.org/10.1016/j.ebiom.2017.09.013.

[5]Ho, Ming, Yin-Yi Chang, Wei-Chun Chang, Hung-Chih Lin, Mei-Hung Wang, Wu-Chou Lin, and Tsan-Hung Chiu. “OralLactobacillus rhamnosusGR-1 andLactobacillus reuteriRC-14 to reduce Group BStreptococcuscolonization in pregnant women: A randomized controlled trial.Taiwanese Journal of Obstetrics and Gynecology55, no 4 (August 1, 2016): 515‑18.https://doi.org/10.1016/j.tjog.2016.06.003.

[6]Sabaté, Jean-Marc, and Franck Iglicki. “Effect of Bifidobacterium Longum 35624 on Disease Severity and Quality of Life in Patients with Irritable Bowel Syndrome”.World Journal of Gastroenterology28, no 7 (February 21, 2022): 732.https://doi.org/10.3748/wjg.v28.i7.732.

[7]Solovyeva andal. “Long-term probiotic administration for irritable bowel syndrome: a legal need”.Therapeutic archives95, no. 8 (October 11, 2023): 679‑85.https://doi.org/10.26442/00403660.2023.08.202378.

[8]Singer, M., M. Borg, S. Ouburg, and SA Morré. “The relationship of the vaginal microbiota to early pregnancy development during in vitro fertilization treatment—A meta-analysis”.Journal of Gynecology Obstetrics and Human Reproduction48, no. 4 (April 1, 2019): 223-29.https://doi.org/10.1016/j.jogoh.2019.01.007.

[9]Haahr, T., JS Jensen, L. Thomsen, L. Duus, K. Rygaard, and P. Humaidan. “Abnormal vaginal microbiota may be associated with poor reproductive outcomes: a prospective study in IVF patients”.Human Reproduction31, no. 4 (April 1, 2016): 795-803.https://doi.org/10.1093/humrep/dew026.

[10]Moreno, Inmaculada, Francisco M. Codoñer, Felipe Vilella, Diana Valbuena, Juan F. Martinez-Blanch, Jorge Jimenez-Almazán, Roberto Alonso, et al. “Evidence That the Endometrial Microbiota Has an Effect on Implantation Success or Failure”.American Journal of Obstetrics and Gynecology215, no 6 (December 2016): 684‑703.https://doi.org/10.1016/j.ajog.2016.09.075.

[11]Souza, Sabrina Vieira de, Paula Bruno Monteiro, Gabriel Acacio de Moura, Nayara Oliveira Santos, Cristina Tonin Beneli Fontanezi, Isadora de Almeida Gomes, and Clara Andrade Teixeira. “Vaginal Microbioma and the Presence of Lactobacillus Spp. as Interferences in Female Fertility: A Review System.”JBRA Assisted Reproduction27, no. 3 (September 2023): 496.https://doi.org/10.5935/1518-0557.20230006.

[12]Gudnadottir, Unnur, Justine W. Debelius, Juan Du, Luisa W. Hugerth, Hanna Danielsson, Ina Schuppe-Koistinen, Emma Fransson, and Nele Brusselaers. “The Vaginal Microbiome and the Risk of Preterm Birth: A Systematic Review and Network Meta-Analysis”.Scientific Reports12, no 1 (May 13, 2022): 7926.https://doi.org/10.1038/s41598-022-12007-9.

[13]Dominguez-Bello, Maria G., Elizabeth K. Costello, Monica Contreras, Magda Magris, Glida Hidalgo, Noah Fierer, and Rob Knight. “Delivery Mode Shapes the Acquisition and Structure of the Initial Microbiota across Multiple Body Habitats in Newborns”.Proceedings of the National Academy of Sciences107, no. 26 (June 29, 2010): 11971‑75.https://doi.org/10.1073/pnas.1002601107.

[14]Slykerman RF, Hood F, Wickens K, Thompson JMD, Barthow C, Murphy R, Kang J, et al. “Effect of Lactobacillus Rhamnosus HN001 in Pregnancy on Postpartum Symptoms of Depression and Anxiety: A Randomized Double-Blind Placebo-Controlled Trial.”EBioMedicine24 (October 2017): 159‑65.https://doi.org/10.1016/j.ebiom.2017.09.013.

[15]Al Kassaa, Imad, and Maher Fuad. “Effects of Lacticaseibacillus Rhamnosus HN001 on Happiness and Mental Well-Being: Findings from a Randomized Controlled Trial”.Nutrients16, no 17 (January 2024): 2936.https://doi.org/10.3390/nu16172936.